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Temprian Therapeutics is developing a novel, safe, and effective treatment for vitiligo.

Woman with vitiligo

‘Temprian’ is an old English word that means ‘to restrain within due limits, to moderate’.

Temprian Therapeutics is a spin-off from Northwestern University. The company's technology is based on over 25 years of research in the areas of gene therapies, autoimmune diseases and dermatology from the labs of Professor Caroline Le Poole.


Prof. Le Poole was the first scientist to show that vitiligo was an autoimmune disease. The lead program is a platform technology to treat autoimmune diseases such as vitiligo.

About Us

Vitiligo is a chronic autoimmune disease that causes patches of skin to lose pigmentation. The disease is often triggered by physical and emotional stress, resulting in an autoimmune reaction targeting the pigment cells (melanocytes) of the skin.  The loss of melanocytes disrupts the production of melanin resulting in pale lesions that may spread across the body. The disease is progressive, and does to date not have a definite cure.

Between 35 and 70 million people suffer from vitiligo globally. 10% of the cases are presented in the United States and the European Union. Vitiligo carries a negative societal stigma causing debilitating emotional and financial hardships for patients.

Temprian Therapeutics addresses vitiligo by injecting a genetically modified DNA plasmid that reverses the debilitating immune response. The drug is systemic, meaning that the treatment impacts lesions across the body. As an autoimmune disease vitiligo is associated with a number of comorbidities such as Hashimoto’s Disease and Alopecia Areata potentially addressable with the proposed platform drug.  

Temprian Therapeutics is Developing a Novel Treatment for Vitiligo

Our team is composed of dedicated doctors and business leaders focusing on advancing the field of vitiligo to create a safe and effective treatment for all.

Meet the Team

Sumeet Dagar



Caroline Le Poole CSO of Temprian Therapeutics. Research for Vitiligo.

Caroline Le Poole


CSO & Co-Founder

Kettil Cedarcreutz board memeber of Temprian Therapeutics for Vitiligo.

Kettil Cedercreutz


Board Member & Co-Founder

Paul Burton CFO of Temprian Therapeutics.

Paul Burton


CFO & Board Member

Modestus Obochi board member of Temprian Therapeutics.

Modestus Obochi


Commercialization & Board Member

Mukesh Kumar regulatory affairs for Temprian Therapeutics.

Mukesh Kumar

Regulatory Affairs

John Nieland cheif innovation officer for Temprian Therapeutics.

John Nieland

Chief Innovation Officer

Pearl Grimes clinical advisor for Temprian Therapeutics.

Pearl Grimes

Clinical Advisor

What is Vitiligo?

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